RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.
Máté Nászai1,3,4, Karen Bellec1,3, Yachuan Yu1,2,3, Álvaro Román-Fernández2,3, Emma Sandilands2,3, Joel Johansson2, Andrew D Campbell2, Jim C Norman2,3, Owen J Sansom2,3, David M Bryant2,3, Julia B Cordero1,2,3* 
1 Wolfson Wohl Cancer Research Centre, Glasgow, G61 1QH, United Kingdom
2 Cancer Research UK Beatson Institute, Glasgow, G61 1BD, United Kingdom
3 Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, United Kingdom
4 Present address: St Peter's College, University of Oxford, Oxford OX1 2DL, United Kingdom

*Correspondence: Julia.Cordero@glasgow.ac.uk

Data organization:
-	1 folder per figure named Figure X or Figure X - supplement Y (for supplementary figures), hereafter called figure folder.
-	Each figure folder contains a pdf version of the relevant figure itself.
-	Each figure folder contains 1 subfolder per each panel of the figure named the letter of the panel (from A, B, C… etc), hereafter referred to as panel folder.
-	Panel folders corresponding to panels that depict representative images contain a folder named Images with files in .tif and/or .czi file formats.
-	Panel folders corresponding to quantitative data contain:
o	GraphPad Prism file in .pzfx format and/or Microsoft Excel spreadsheet in .xlsx format of the data and statistics presented in the panel.
o	Vector graphics file in either .eps or .emf format used in publication.
o	If based on image quantification, folder called RawData that contains all images used to create the panel in .czi format.
o	If based on RT-qPCR, folder called RawData that contains .eds files as created by Applied Biosystems 7500 Real-Time PCR Software and/or .xls files that contain exported raw data.
o	If based on ELISA data, folder called RawData that contains .xls files with absorbance values as exported from the plate reader, and calculations to derive percentage internalisation.
o	If based on cyst size quantification, folder called RawData that contains .xls and .txt files as exported from the Opera high content imaging software.
-	1 README file describing organisation data.

Additional data availability
RNA sequencing data has been deposited in GEO (accession GSE162421) and can be accessed through (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE162421). Custom scripts used for quantification are available at (https://github.com/emltwc).
Methods
List of materials used and a description of methods to generate data are available in the manuscript.